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Targeting hypoxic tumor microenvironment in pancreatic cancer

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Gut microbial metabolic processes of dietary polyphenols and procyanidins have been detailed in various reviews ( 6.1 Pre-systemic metabolism: role of gut microbiota Although some oligomeric or polymeric procyanidins might be already subjected to microbial metabolism in the small intestine ( Akkermansia muciniphila , and butyrate-producing bacteria while inhibiting LPS-producing bacteria (Figure 3)

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