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After controlling for several variables, including sex, age, history of polyps, medical conditions, medications, BMI, and another CRC-related nutritional status, the association between riboflavin and CRC risk remained and showed a dose-response link (104)

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As clinical signs of cobalamin deficiency include chronic wasting or failure to thrive, malaise, and gastrointestinal signs such as diarrhea, serum cobalamin concentration should be measured in any dog with poor response to enzyme replacement therapy for EPI