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Study appraisal and synthesis methods We assessed the quality of studies using the RoB2 tool recommended by the Cochrane Handbook, the NewcastleOttawa Quality Assessment Scale (NOS), the checklist recommended by Agency for Healthcare Research and Quality (AHRQ), and the quality evaluation tool recommended by the National Institutes of Health (NIH)

While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

The label is clear and easy to read