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What Current Evidence Says About GLP-1 Drugs and IBS Direct, large-scale clinical trials of semaglutide specifically for IBS are lacking
According to NICE guidance (TA875 and TA664), GLP-1 medications for weight management should be used within specialist weight management services and are typically time-limited
Therefore, any relationship between GLP-1 therapy and muscle cramps is more likely to be indirect, mediated through secondary metabolic, nutritional, or fluid balance alterations rather than through direct receptor-mediated effects on muscle tissue
Each component has been independently studied for its proposed role in appetite regulation, glucose control, and gastric motility
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