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Key timing considerations: Side effect profile tends to be somewhat milder than semaglutide, which may reduce the importance of sleep-through timing Same 48-hour minimum spacing rule applies if changing injection days Pre-filled pen format means no reconstitution time, making spontaneous timing adjustments easier Many dulaglutide users report minimal side effects after the first month, at which point timing becomes purely a convenience decision Retatrutide (weekly injectable, investigational) Dosing frequency: Once weekly Half-life: Data from Phase 2 trials suggest approximately 6 days Peak concentration: Approximately 24 to 72 hours after injection Recommended timing approach: As a triple agonist (GLP-1/GIP/glucagon), retatrutide may produce a different side effect profile than pure GLP-1 or dual GLP-1/GIP agonists

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As MBS leaderand Accomplish Health advisorJOHN MORTON puts it: Combining surgical approaches and GLP-1 receptor agonist therapy presents an opportunity to further improve outcomes for patients undergoing MBS. --- Review: Combining Medications With Bariatric Surgery to Treat Obesity To view or add a comment, sign in Compared with GLP-1 RAs, bariatric metabolic surgery was associated with lower rates of: All-cause mortality Major adverse cardiovascular events (MACE) Nephropathy Retinopathy These findings indicate that even with the availability of GLP-1 RAs, metabolic surgery remains superior to medical treatment for macrovascular and microvascular outcomes in patients with diabetes and obesity

group is funded by a Wellcome Trust Career Development Award (227745/Z/23/Z)