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Likewise, knockout or knockdown of FATP5 in mice reduces hepatocyte fatty acid uptake, hepatic triglyceride content, and reverses steatosis [16, 17] indicating a role of FATP-mediated lipid uptake as a facilitator of hepatic steatosis

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The direct cardioprotective effects of GLP-1 RAs encompass the reduction of inflammation, the lowering of oxidative stress, the decrease of fibrosis, the regulation of lipids, and the preservation of mitochondrial function